Database→TB4-SO
Tier 4Anti-inflammatoryCardiacWound HealingPREMIUM

TB4-SO

Thymosin Beta-4 Sulfoxide (Tbeta4-SO) -- Endogenous Oxidation Derivative of Thymosin Beta-4, Inflammation Resolution Signal
Not FDA-approved for any indication. No IND applications on public record for Tβ4-SO specifically. No human clinical trials registered for Tβ4-SO. WADA status: Tβ4-SO is a direct oxidation derivative of thymosin beta-4, which is explicitly prohibited under the WADA 2026 Prohibited List (S2, Peptide Hormones and Growth Factors, and related substances). Athletes should treat TB4-SO as prohibited. Not commercially available as a pharmaceutical or supplement.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

Thymosin beta-4 sulfoxide (Tβ4-SO) is a naturally occurring oxidation derivative of the parent peptide thymosin beta-4, formed when the methionine-6 residue of Tβ4 is oxidized by hydrogen peroxide (H2O2) at sites of inflammation. It is a distinct compound from its parent: oxidation attenuates Tβ4's intracellular G-actin sequestering function but substantially enhances its extracellular anti-inflammatory and immune-resolution signaling. TB4-SO is not the same compound as TB-500 (the actin-binding fragment Ac-LKKTETQ used in the peptide community) nor the same as Tβ4 itself. Evidence is limited to two key publications: the 1999 Young et al. Nature Medicine paper establishing glucocorticoid-induced monocyte production and in vitro/in vivo anti-inflammatory effects, and the 2013 Evans et al. Nature Communications paper demonstrating cardiac wound healing promotion in zebrafish, mouse, and human cell culture. No human clinical trials have been conducted.

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Full Profile: Premium Members Only

The complete TB4-SO profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use