DatabasePinealon
Tier 3-4NeuroprotectionCognitive HealthAnti-AgingPREMIUM

Pinealon

Glu-Asp-Arg (EDR Tripeptide)
Research compound only; no FDA or EMA approval; not scheduled; sold commercially as supplement and in clinical use within Russia through the St. Petersburg Institute; European and Israeli patents held

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

Pinealon (Glu-Asp-Arg, EDR) is a synthetic tripeptide isolated from the polypeptide neuroprotective drug Cortexin and developed by the St. Petersburg Institute of Bioregulation and Gerontology. It is the most clinically supported Khavinson bioregulator other than Pancragen: oral administration in 72 patients with traumatic brain injury consequences (0.2 mg twice daily, 20 to 30 days, with a 37-patient control group) produced improvements in memory, headache reduction, emotional stability, and EEG alpha-index changes. Additional published rodent data include prenatal neuroprotection, hypoxia tolerance, cognitive improvement across aging models, and dendritic spine preservation in Alzheimer's and Huntington's disease cell models. The 2021 MDPI Molecules open-access review provides the most comprehensive mechanistic characterization to date. No randomized controlled trial has been published.

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Full Profile: Premium Members Only

The complete Pinealon profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use