Database→Oxytocin

Tier 2-3ReproductiveSocial FunctionMoodPREMIUM

Oxytocin

Oxytocin (Pitocin / Syntocinon) -- Endogenous Nonapeptide Hormone, Oxytocin Receptor Agonist

FDA-approved (Pitocin, Syntocinon) for IV/IM obstetric use only: labor induction, labor augmentation, postpartum hemorrhage control, and management of incomplete abortion. The Syntocinon brand intranasal formulation was historically FDA-approved for milk ejection but has been discontinued in the USA. Intranasal oxytocin for behavioral or social indications (autism, social anxiety, bonding) is not FDA-approved for any indication. Compounded intranasal oxytocin sprays are legally available through Section 503A compounding pharmacies in the USA with a valid prescription. Not on WADA 2026 Prohibited List.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

Oxytocin is an endogenous nonapeptide hormone synthesized in the hypothalamus with FDA-approved obstetric uses. Intranasal oxytocin for behavioral indications has been extensively studied but has not achieved regulatory approval for any social, cognitive, or psychiatric indication. The largest RCT to date -- Sikich et al. (2021, NEJM), n=290 children with autism, 24 weeks -- was fully negative on the primary endpoint (ABC-mSW difference: -0.2, p=0.61). Acute single-dose studies in healthy adults consistently show small improvements in emotion recognition, but chronic treatment trials have failed to replicate these effects on clinical outcomes.

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Full Profile: Premium Members Only

The complete Oxytocin profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use