Database→Melanotan II

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Melanotan II

Melanotan II (MT-II) -- Cyclic Alpha-MSH Analog, Non-Selective Melanocortin Receptor Agonist

Not approved by FDA, EMA, TGA (Australia), MHRA (UK), or any other major regulatory authority for any indication. Clinical development was formally halted due to safety concerns. FDA issued warning letters to sellers beginning in 2007 and pursued criminal prosecution of one distributor. FDA explicitly classifies Melanotan II as an unapproved new drug. Illegal to sell in all 50 US states and in the UK and Australia. Sold in grey markets as a 'research chemical' with no quality or dosing verification. WADA status: not named explicitly on the 2026 Prohibited List, but potentially captured under S0 (non-approved substances prohibited at all times); athletes should treat as prohibited.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

Melanotan II (MT-II) is a synthetic cyclic lactam analog of alpha-melanocyte-stimulating hormone, developed in the late 1980s at the University of Arizona. It is the parent compound from which bremelanotide (PT-141, FDA-approved for HSDD) was derived. MT-II has Phase 1 and small Phase 2 human data demonstrating reliable skin tanning (Dorr et al., 1996) and potent erectogenic effects (Wessells et al., 1998 and 2000). Clinical development was formally abandoned due to the combination of severe nausea side effects and melanoma safety concerns. It is now sold exclusively through unregulated grey markets, a status associated with documented product contamination, dosing inaccuracy, eruptive naevi, and case reports of melanoma.

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The complete Melanotan II profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use