Database→IGF-1 LR3
Tier 4HormonalAnti-agingMetabolicPREMIUM

IGF-1 LR3

Long Arginine 3-IGF-1 / LR3-IGF-1 / IGF-1 LR3 -- 83-Amino Acid Synthetic IGF-1 Analogue
Not FDA-approved for any human indication. Never submitted for IND review. No completed human clinical trials of any kind. The only FDA-approved IGF-1 product is mecasermin (Increlex), which is native recombinant human IGF-1, a chemically distinct molecule approved for severe primary IGF-1 deficiency in children. IGF-1 LR3 has no regulatory history as a human drug. WADA prohibited at all times (growth factors and related substances, Section S2). DoD Prohibited Dietary Supplement Ingredients List. Sold exclusively as a laboratory research reagent; use as a research chemical or performance-enhancing compound is outside any approved or regulated framework.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

IGF-1 LR3 is an 83-amino-acid synthetic analogue of human IGF-1, engineered with two structural modifications that reduce binding to IGF-binding proteins (IGFBPs) by approximately 1,000-fold and extend half-life from the native IGF-1's 10 to 15 minutes to approximately 20 to 30 hours. It is primarily used as a cell culture additive for maintaining human pluripotent stem cells, organoids, and biopharmaceutical production. Zero human clinical trials have been completed. All anabolic, body composition, and recovery claims originate from animal studies and mechanistic extrapolation from native IGF-1 data. The cancer risk signal from IGF-1 receptor biology is the most significant safety concern and is unsettled. This is the highest-risk compound in this research series from an evidence-to-use-pattern mismatch perspective.

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Full Profile: Premium Members Only

The complete IGF-1 LR3 profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use