Database→Gonadorelin

Tier 1-2HormonalReproductiveFertilityPREMIUM

Gonadorelin

Gonadorelin -- Synthetic Gonadotropin-Releasing Hormone (GnRH), Hypothalamic Decapeptide

FDA-approved human products (Factrel for diagnostic use, Lutrepulse for ovulation induction in hypothalamic amenorrhea) were approved but are commercially discontinued in the US. Veterinary Factrel (Fort Dodge Animal Health) remains commercially available. Gonadorelin is available via compounding pharmacies under 503A for human use. WADA PROHIBITED under S2.2.1 (Releasing Factors) at all times in competition and out of competition.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

Gonadorelin is a synthetic decapeptide identical in sequence to endogenous gonadotropin-releasing hormone (GnRH), the hypothalamic master regulator of the reproductive axis. It stimulates pituitary release of LH and FSH, which in turn drive gonadal steroidogenesis and gametogenesis. FDA-approved formulations existed for diagnostic use and pulsatile ovulation induction but are commercially discontinued; compounding remains active. Its primary documented clinical utility is pulsatile pump delivery for hypothalamic amenorrhea (70 to 100% pregnancy rates in responsive cases) and spermatogenesis induction in CHH. The dominant current community use as a daily subcutaneous injection TRT adjunct lacks pharmacokinetic rationale given gonadorelin's 10 to 40 minute half-life.

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Full Profile: Premium Members Only

The complete Gonadorelin profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use