Database→AHK-Cu

Tier 4HairSkinPREMIUM

AHK-Cu

AHK-Cu (Copper Tripeptide-3; L-Alanyl-L-Histidyl-L-Lysine-Cu2+)

Cosmetic ingredient only. INCI name: Copper Tripeptide-3. Regulated by FDA as a cosmetic, not a drug. No drug approval exists or has been sought. Not WADA-listed. Not a scheduled or controlled substance. Not a naturally occurring human peptide (fully synthetic; distinct from GHK-Cu which is endogenous).

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use

Profile Overview

AHK-Cu (Copper Tripeptide-3) is a synthetic copper-chelated tripeptide composed of alanine-histidine-lysine, differing from the naturally occurring GHK-Cu by a single amino acid substitution (alanine replaces glycine at position 1). Its entire published evidence base consists of one study: Pyo et al. (2007, Archives of Pharmacal Research), an ex vivo organ culture study showing statistically significant hair follicle elongation (p less than 0.001) and increased dermal papilla cell proliferation at picomolar-to-nanomolar concentrations from 240 human hair follicles across 3 donors. Anti-apoptotic protein markers shifted but apoptosis reduction was not statistically significant. No human clinical trial of AHK-Cu has been published.

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Full Profile: Premium Members Only

The complete AHK-Cu profile includes all use cases with full evidence reviews, mechanism of action deep dive, safety analysis, evidence table, dosing guidance, and stack compatibility data.

For research and educational purposes only · Not medical advice · Consult a qualified physician before any human use